Resident evil: inflammation and depression

By Leah Kivivali, La Trobe University

Inflammation. When most of us think of inflammation, we probably think about a swollen joint or swelling around a wound, but can inflammation also affect our brains. Ultimately, inflammation is good. It’s the process whereby our body eradicates invading pathogens and helps us fight disease. However, inflammation can turn bad when the signalling to turn it off after the threat has gone doesn’t work.

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Fibrosis: an overlooked companion of inflammation

By Conor Sugden, University of Liverpool

Inflammatory mechanisms and processes contribute to the pathogenesis of a number of conditions – one of which is fibrosis. Inflammation and fibrosis are intrinsically linked, and much about their complex relationship is still unknown. Whereas a healthy inflammatory response is necessary for successful wound healing, a prolonged response often precedes tissue fibrosis.

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