The Biochemist Blog

Why can tendons tell time?

By Chloé Yeung, Institute of Sports Medicine Copenhagen, Denmark

At the start of October, the 2017 Nobel Prize in Physiology or Medicine was awarded jointly to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their discoveries of molecular mechanisms controlling the circadian rhythm. In recent years, the very same molecular mechanisms have been discovered in our peripheral tissues and we’re now beginning to understand why circadian rhythms are also needed in our musculoskeletal tissues.

Accessing our inner clock

By Helen Albert, Editor

We all have an inner clock that allows us to respond appropriately to our immediate environment according to the time of day or night. The existence of such biological clocks has been known about for some time, but the specific mechanism of action was unclear. In the 1980s, three American scientists – Jeffrey Hall, Michael Rosbash and Michael Young – succeeded in isolating a gene called period that had previously been linked with disruption of the biological clock in fruit flies.