Most biologists would agree that the most extraordinary development of the 21st century has been the discovery and manipulation of the CRISPR/Cas9 method of gene editing – a natural defence mechanism that bacteria use to defend against viral infection which scientists have hijacked to modify the DNA sequence of living cells. Continue reading Prime editing – a cutting edge new development in genomic engineering
This article discusses the events that follow a viral infection and reveals how an extended period of self-targeting, a side-effect that is otherwise associated with immunity, is minimised so as to avoid cell death. Continue reading The hidden power of type III CRISPR immunity: how a prokaryote avoids an autoimmune catastrophe
By Ralitsa Madsen, Institute of Metabolic Science, Cambridge, UK
As a driven PhD student who is dedicating most of my waking hours to a very ambitious project, I often need to justify my choice to others. Wouldn’t I be set up for success with fewer hours in the lab, less scientific reading and a bit more faith in my own talent? My usual response is to ask the following question: how do elite athletes succeed?
By Anastasia Stefanidou, Communications Officer, Biochemical Society
Gene editing and the use of CRISPR to fix genetic disease in human embryos seem to be all over the news these days.
It has just been reported that a team of American and South Korean scientists have successfully used CRISPR, a tool that cuts DNA with more precision than any other genome editing technology, to fix a genetic defect in human embryos that can cause serious heart problems. Continue reading “An introduction to gene editing”