Fibrosis: an overlooked companion of inflammation

By Conor Sugden, University of Liverpool

Inflammatory mechanisms and processes contribute to the pathogenesis of a number of conditions – one of which is fibrosis. Inflammation and fibrosis are intrinsically linked, and much about their complex relationship is still unknown. Whereas a healthy inflammatory response is necessary for successful wound healing, a prolonged response often precedes tissue fibrosis.

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Spotlight on cerebral small vessel disease

By Rosalind Brown, Centre for Clinical Brain Sciences, University of Edinburgh

Most people will have heard of Alzheimer’s disease, but fewer people are aware of cerebral small vessel disease (SVD), a silently progressing disease of ageing responsible for nearly half of all cases of dementia along with a large percentage of strokes. The global health impact of SVD is huge and while a small number of genetic mutations have been identified as causing some forms, for the majority of cases the cause is uncertain.

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