Trypanosoma brucei: epigenetic regulation and coat switching

By Zandile Nare, University of Edinburgh

Trypanosoma brucei is a parasite which is responsible for causing African sleeping sickness and nagana in cattle in sub-Saharan Africa. Cell differentiation in T. brucei is associated with the upregulation and downregulation of several genes some of which seem to be regulated by epigenetic mechanisms. T. brucei could therefore be a key tool in advancing knowledge in this field.

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