Blood vessel growth and metabolic stress

By Sayan Chakraborty, Senior Researcher at the Institute of Molecular and Cell Biology, A-STAR, Singapore

In our hectic modern lifestyle, we are constantly subjected to stress of many kinds including the stress experienced by our body from weight-gain. From the physiological perspective, these symptoms are managed by signalling molecules present in the body that control energy expenditure and form new blood vessels (angiogenesis) to cope with increased ‘cellular stress’ levels. These physiological consequences can be precursors to conditions such as type 2 diabetes, one symptom of which is increased angiogenesis.

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Proliferative retinopathy, an advanced form of diabetic retinopathy, occurs when abnormal new blood vessels and scar tissue form on the surface of the retina. (Credit: National Eye Institute, National Institutes of Health, USA) Continue reading “Blood vessel growth and metabolic stress”