Trypanosoma brucei: epigenetic regulation and coat switching

By Zandile Nare, University of Edinburgh

Trypanosoma brucei is a parasite which is responsible for causing African sleeping sickness and nagana in cattle in sub-Saharan Africa. Cell differentiation in T. brucei is associated with the upregulation and downregulation of several genes some of which seem to be regulated by epigenetic mechanisms. T. brucei could therefore be a key tool in advancing knowledge in this field.

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Finding the founding fathers of molecular biology

By Lisa Strittmatter, University of Cambridge, UK

My motivation to do a PhD at the MRC Laboratory of Molecular Biology in Cambridge was driven by its place at the forefront of science. During my time here, I have come to realise how little I know about the origins of molecular biology. In 1957, the MRC institute was named ‘unit for Molecular Biology’. I decided it was high time to find out more and who better to narrate its history than its contemporary witnesses?

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PhD reflections 2.0: let’s reboot

By Ralitsa Madsen, University of Cambridge

“Software Update. iOS 8.0 is ready to install. To install the update, make sure your iPhone is connected to its charger.”

Every iPhone user gets this notification on a regular basis. I am sure other smartphone systems have similar setups. Note how important it is that the hardware is charged. If it is not, the software can’t be installed. In fact, a completely dead battery means that not even the old software will be running.

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