Current estimates state that nearly half of us will develop cancer at some point during our lifetime, either a benign tumour that doesn’t require treatment or a more aggressive malignant tumour with the potential to kill.
By Ralitsa Madsen, Institute of Metabolic Science, Cambridge, UK
Iris, the Greek Goddess messenger between humans on Earth and the Gods on Mount Olympus, has made an entry into human biology by providing inspiration for the name of a skeletal muscle-derived hormone. Irisin belongs to the class of myokines, which are molecules released by skeletal muscle in response to exercise and act as messengers to other tissues, including liver, fat and the brain. Given the beneficial effects of exercise, particularly in the context of obesity and Type 2 Diabetes, major efforts have been invested into discovering myokines of potential therapeutic value. Irisin seems to have it all, with multiple animal studies confirming its metabolic benefits such as lowering of blood glucose and lipid levels. Continue reading “The metabolic benefits of exercise”
By Tilly Potter, Department of Twin Research, King’s College London
I recently began my PhD during which I will be carrying out investigations into the human microbiome – that is, all of the microbes we harbour on and in our bodies and their genetic material. The reasons why I was attracted to this area are likely similar to those of other scientists who have entered this field; microbiome research is still in its relative infancy yet appears to hold enormous potential regarding understanding differences between health and disease, with the number of diseases or adverse health states examined continuing to increase with time. This makes it an incredibly diverse and exciting area to work within! Continue reading “Microbiome manipulation – full steam ahead?”
Currently, there is much interest in the ageing brain and how people can take measures to counteract the decline in mental function that appears to be an inevitable consequence of growing older. The World Health Organization predicts that between 2015 and 2050, the proportion of the world’s population aged over 60 will nearly double, from 12% to 22%. So more people are living for longer, meaning that age-related disease and disability is a major and escalating concern for society.
The term ‘cognitive decline’ is often used to describe the deterioration in some aspects of brain function that occurs with age. Dementia is used to define a decline in mental ability that is severe enough to interfere with daily life. It is characterized by memory loss and by difficulties with thinking, problem-solving or communicating. There are several causes of dementia, with Alzheimer’s disease being the most common type, followed by vascular dementia. Continue reading “Counteracting cognitive decline & dementia”